Abstract: To address the issue that tetracycline antibiotic pollutants are accumulating in water andcausing serious harm to human health and the ecological environment, this study prepared a novel com⁃posite material of CoFe2O4 / MnO2 and used it as a highly efficient permonosulfate (PMS) activator forthe degradation of tetracycline hydrochloride (TCH) in the water body. The degradation results showedthat the CoFe2 O4 / MnO2 - PMS system had outstanding TCH removal efficiency, which could reach92.7% after 40 min of reaction, much higher than that of the single catalyst-PMS system. The resultsof the influencing factor experiments showed that the CoFe2O4 / MnO2 -PMS degradation system had awide range of pH suitability and a stable degradation activity in the presence of various anions. In addi⁃tion, the CoFe2 O4 / MnO2 -PMS degradation system had good stability and reusability, showing highcatalytic activity and TCH degradation rate after 5 cycles. Mechanistic analysis showed that the valencecycles of Co2+ / Co3+, Fe3+ / Fe2+ and Mn3+ / Mn4+ existed in the CoFe2O4 / MnO2 composites to participatein the electron transfer process during the catalytic PMS degradation of TCH, leading to the full releaseof SO4· and ·OH during the activation process and the effective degradation of TCH through a seriesof typical chain reactions.