Abstract: In recent years, with the improvement of living standards, the production and use of phar⁃maceutical increased sharply in our country, and pharmaceutical and personal care products (PPCPs)is also growing rapidly, which leads to the continuous existence of emerging contaminants such as phar⁃maceuticals and PPCPs in the water environment, with antibiotic pharmaceutical contamination beingparticularly prominent. At present, advanced oxidation technology of persulfate is regarded as a promis⁃ing water purification technology due to its advantages such as short reaction time, high degradation ef⁃ficiency and wide application range. This review firstly introduces the use and pollution status of antibi⁃otics in China, and analyzes the source and migration process of antibiotics, then systematically ex⁃pounds the activation system of persulfate (heat activation, radiation activation, ultrasonic activationand heterogeneous activation of metal/ non-metallic catalysts), and discusses the degradation mecha⁃nism of advanced oxidation technology of persulfate on antibiotics ( radical and non -radical mecha⁃nisms). Finally, the existing problems of this research direction are analyzed, and the future develop⁃ment direction is prospected. This review is expected to provide useful information for the practical ap⁃plication of persulfate advanced oxidation process in the degradation of antibiotics.