Based on the status of heavy metal pollution in soil and vegetation in the manganese mining area in Guangxi Province, the regional distribution characteristics and hazards of heavy metals were analyzed, and control measures were proposed. The results show that the soil and vegetation in Guangxi manganese mining area are all polluted by multiple heavy metal elements. All the mining areas are heavily polluted by Mn and Cd. The moderately and slightly polluted elements shows regional differences. Heavy metal pollution mainly distributes in highly-developed mining areas with high mineral reserves. Hyperaccumulator plants have a significant repair effect on heavy metal pollution. It is recommended to strengthen the screening and cultivation of hyperaccumulator plants.