A polyeyelic aromatie hydrcarbons (PAHs) contaminated site in Chongqing was selected as the research object, and the chemical oxidation remediation technology was studied by using a variety of free radicals with strong oxidizing to remediate the contaminated soil. The effect of inorganic agents and organic compound agents on the removal rate of polycyclic aromatic hydrocarbons in the soil was discussed. The results showed that the oxidation effect of activated sodium persulfate was the best among the oxidation systems of Fenton reagent, calcium peroxide, potassium permanganate and activated sodium persulfate. The optimum dosage of sodium persulfate was 15 times of stoichiometric oxidant demand (SOD).Compared with adding activated sodium persulfate alone, the oxidation repair effect of activated sodium persulfate combined with a littlle citric acid was better. The removal rate of PAHs in soil was more than 92%, when the molar ratio of ferrous sulfate, sodium persulfate and citric acid was 4:1:1, the dosage of sodium persulfate was 15 times of SOD, and the curing time was 6 days. The content of residual PAHs was lower than the screening value of type I land use in soil environmental quality—risk control standard for soil contamination of development land (GB 36600—2018).