Taking the cultivated soil around the old mining area in southern Yunnan as the research object, the remediation of lead-contaminated soil by the eutectic ionic liquid + malic acid leaching system were studied. The leaching process conditions were optimized by response surface method. A new leaching remediation system which was suited to lead-contaminated soil was constructed. The results show that the leaching effect of choline chloride/urea-malic acid is the best,and the removal rate of lead is 72.29%. The removal rate of lead is 73.13%, when the malic acid concentration is 0.76 mol/L, the choline chloride/urea concentration is 6%, and the oscillation time of 5.05 h. This removal rate is similar to the predicted value and is better than the result of the single-factor experiment. In addition, this removal rate is 9.51% higher than that of the system without ionic liquid leaching.