The advantages of carbon materials and Al2O3 as catalyst support were complementary, and a new Mn-Ce/C-Al2O3 catalyst was developed by wrapping carbon on the outer side of Al2O3. The effects of preparation parameters on the degradation of organic compounds in simulated coking wastewater containing phenol were studied, and the stability of the catalyst was investigated. The results showed that the specific surface area of the catalyst increased by 26.36% after carbon loading with 6% glucose solution. The Lewis acid point provided by the loading of manganese promoted the process of ozone activation to ·OH,and cerium enhanced the catalytic effect of manganese. When the ratio of Mn to Ce was 4 ∶ 1 and the baking time was 4 hours at 450 ℃, the degradation rates of COD, TOC and UV254 could reach 85.52%, 86.06% and 90.96%, respectively. In 10 degradation experiments, the COD removal efficiency of the catalyst was stable, with an average of 77.5%. Mn-Ce/C-Al2O3 catalyst had good catalytic activity and stability.