In order to solve the scaling problem of the high salinity mine water reverse osmosis system, a process of "chemical softening + ion exchange softening" was used to remove calcium, magnesium and silicon synergistically from the reverse osmosis concentrated water with a total hardness of 2 800 mg /L. The results showed that the optimum dosages of Ca(OH)2 and Na2CO3 were 550 mg/L and 3 500 mg/L, respectively. The optimum reaction time was 30 minutes. Under the above conditions, the effluent hardness was 188 mg /L and the total hardness removal efficiency was 93.29%. The optimum resin model was D402 and the optimum flow rate was 15 m/h. Under the above conditions, the effluent hardness was not detected. The silica content was decreased to 1.61 mg /L, and the corresponding removal efficiency was 92.3% by the collaborative process.