The neutralization-precipitation method and adsorption method were used separately to treat simulated Zn2+ wastewater. The influence of the dosage of alkali, initial concentration of Zn2+ and the dosage of molecular sieves on treatment effect was investigated. The FTIR technology was used to characterize the structure of the molecular sieves before and after use. Under the optimum dosage of alkali and molecular sieves, the neutralization-precipitation combined adsorption process was used to treat laboratory wastewater produced during the determination process of the enthalpy of chemical reactions. The results showed that when the ratio of n(OH-)/n(Zn2+) was 2, the treating effect of neutralization-precipitation method was optimal and the pH value of effluent was 6.8. When the initial concentration of Zn2+was 10~40 mg/L and the dosage of molecular sieves was 50 g/L, the residual concentration of Zn2+ decreased to 1.0~3.0 mg/L, and the mass loss rate of molecular sieves was 0.5%~3.8%. The FTIR analysis illustrated that Zn2+in the solution entered into the molecular sieves and formed new chemical bonds. Under the optimal conditions, the concentrations of Zn2+, Cu2+ and pH value in the effluent treated by neutralization-precipitation combined adsorption were 2.4 mg/L,0.2 mg/L and 6.8, respectively, which met the secondary emission standards of GB 8978—1996.